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Antigen incorporation into liposomes results in the enhancement of IL-4 and IgG1 secretion: evidence for preferential expansion of Th-2 cells.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Antigen incorporation into liposomes results in the enhancement of IL-4 and IgG1 secretion: evidence for preferential expansion of Th-2 cells.
 
Creator Agrewala, J N
Owais, M
Gupta, C M
Mishra, G C
 
Subject QR180 Immunology
 
Description Liposomes have been used to modify the immunological behaviour of a number of antigens. The present study was designed to evaluate the effect of liposomization of ovalbumin on the induction of Th-1 and Th-2-cell response by monitoring the secretion of lymphokines and IgG Isotypes. Liposomes having varied physicochemical properties (positively and negatively charged, neutral and pH-sensitive) were used for this purpose. Ovalbumin delivered in this way induced preferential secretion of IL-4 and production of antigen-specific IgG1 isotypes. This was observed irrespective of the surface charge properties of the liposomes. Further, the concentration of antigen required for the activation of Th cells was 10(2)- to 10(3)-fold lower after encapsulating it in liposomes. These results suggest that liposomes may prove useful adjuvants to prime Th2-like immune responses.
 
Publisher Martin Dunitz Publishers
 
Date 1996-03
 
Type Article
PeerReviewed
 
Identifier Agrewala, J N and Owais, M and Gupta, C M and Mishra, G C (1996) Antigen incorporation into liposomes results in the enhancement of IL-4 and IgG1 secretion: evidence for preferential expansion of Th-2 cells. Cytokines and molecular therapy, 2 (1). pp. 59-65. ISSN 1355-6568
 
Relation http://crdd.osdd.net/open/384/