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Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells.
 
Creator Majumder, S
Gupta, R
 
Subject QR Microbiology
 
Description The effect of mouse recombinant interleukin-1 alpha on the intracellular growth of Mycobacterium microti in a murine macrophage cell line J774A.1 was investigated. Interleukin-1 alpha added after infection to the M. microti-infected macrophage monolayers enhanced the growth of M. microti in a concentration-dependent manner and this growth enhancement was abrogated by neutralization of interleukin-1 alpha with anti-interleukin-1 alpha antibody. Cyclic adenosine monophosphate level in J774A.1 cells was increased by the addition of interleukin-1 alpha. Addition of dibutyryl cyclic adenosine monophosphate to infected J774A.1 cells increased the number of intracellular bacteria in a concentration-dependent manner. These results suggest that interleukin-1 alpha acts as a growth enhancer for intracellular M. microti and the growth enhancing effect of interleukin-1 alpha may be due to enhanced cellular cyclic adenosine monophosphate level.
 
Publisher Elsevier Science
 
Date 1994-07-15
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/406/1/majumdar94.pdf
Majumder, S and Gupta, R (1994) Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells. FEMS microbiology letters, 120 (3). pp. 329-34. ISSN 0378-1097
 
Relation http://www.sciencedirect.com/science/article/pii/0378109794904928
http://crdd.osdd.net/open/406/