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Use of specific polyclonal antibodies for site specific drug targeting to malaria infected erythrocytes in vivo.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Use of specific polyclonal antibodies for site specific drug targeting to malaria infected erythrocytes in vivo.
 
Creator Singh, A M
Owais, M
Varshney, Grish C
 
Subject QD Chemistry
 
Description The possibility of using specific polyclonal antibodies for effective site specific drug targeting to malaria infected erythrocytes has been examined. For this purpose, rabbit polyclonal antiserum was raised against Plasmodium berghei infected mouse erythrocytes (IRBC) and extensively absorbed with normal erythrocytes (NRBC). Absorbed antiserum specifically recognized IRBC. F(ab')2-fragments of these antibodies were coupled to chloroquine (chq) laden liposomes. These immunoliposomes when tested in vivo significantly suppressed malarial infection in mice.
 
Publisher NISCAIR
 
Date 1993-12
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/413/1/Varshney1993.pdf
Singh, A M and Owais, M and Varshney, Grish C (1993) Use of specific polyclonal antibodies for site specific drug targeting to malaria infected erythrocytes in vivo. Indian journal of biochemistry & biophysics, 30 (6). pp. 411-3. ISSN 0301-1208
 
Relation http://crdd.osdd.net/open/413/