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Transformation of rifamycin B with growing and resting cells of Curvularia lunata.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Transformation of rifamycin B with growing and resting cells of Curvularia lunata.
 
Creator Banerjee, U C
 
Subject QR Microbiology
 
Description Growing and resting cell systems of Curvularia lunata were used for the transformation of rifamycin B to rifamycin S. In the case of growing cells, rifamycin B was added at the time of inoculation and at the different phases of growth. Interestingly, it was found that C. lunata could grow in the presence of rifamycin B and could convert rifamycin B to rifamycin S. Growing cells 24 and 48 h of age were capable of transforming rifamycin B. Resting cells, cultivated at the exponential or early stationary phase, were found to be very active, and the resting cells of different ages were repeatedly used for the transformation reaction. Growing cells of 72 and 96 h were not capable of transforming rifamycin B, whereas resting cells of similar ages were very active. Due to the adsorption of rifamycins by the growing and resting cells of C. lunata, the stoichiometric yield of rifamycin S was not obtained.
 
Publisher Elsevier Science
 
Date 1993-12
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/414/1/banerjee1993.pdf
Banerjee, U C (1993) Transformation of rifamycin B with growing and resting cells of Curvularia lunata. Enzyme and microbial technology, 15 (12). pp. 1037-41. ISSN 0141-0229
 
Relation http://crdd.osdd.net/open/414/