Record Details

Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.
 
Creator Mishra, Nitish K
Agarwal, Sandhya
Raghava, G.P.S.
 
Subject QR Microbiology
 
Description This study demonstrates that SVM based QSAR model can predict substrate specificity of major CYP isoforms with high accuracy. These models can be used to predict isoform responsible for metabolizing a drug molecule. Thus these models can used to understand whether a molecule will be metabolized or not. This is possible to develop highly accurate models for predicting substrate specificity of major isoforms using CDK descriptors. A web server MetaPred has been developed for predicting metabolizing isoform of a drug molecule http://crdd.osdd.net/raghava/metapred/.
 
Publisher BIomedcentral
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/504/1/raghava10.9.pdf
Mishra, Nitish K and Agarwal, Sandhya and Raghava, G.P.S. (2010) Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule. BMC pharmacology, 10. p. 8. ISSN 1471-2210
 
Relation http://www.biomedcentral.com/content/pdf/1471-2210-10-8.pdf
http://crdd.osdd.net/open/504/