Record Details

T cell help to B cells in germinal centers: putting the jigsaw together.

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title T cell help to B cells in germinal centers: putting the jigsaw together.
 
Creator Gowthaman, Uthaman
Chodisetti, Sathi Babu
Agrewala, J N
 
Subject QR180 Immunology
 
Description The germinal center (GC) reaction supports the processes of affinity maturation and class switching in B cells that result in long-lasting humoral immunity. CD4(+) T follicular helper cells (Tfh) participate in the GC reaction to help B cells. However, recent studies highlight the heterogeneity of CD4(+) T cells in GCs, which confounds the understanding of Tfh cells. Based on many recent studies, we have tried to form a working model on the niche of Tfh cells in GCs. We have also addressed whether Tfh cells are a distinct lineage and how they may be generated to help B cells.
 
Publisher Informa healthcare
 
Date 2010-08
 
Type Article
PeerReviewed
 
Relation http://informahealthcare.com/doi/abs/10.3109/08830185.2010.496503
http://crdd.osdd.net/open/505/
 
Identifier Gowthaman, Uthaman and Chodisetti, Sathi Babu and Agrewala, J N (2010) T cell help to B cells in germinal centers: putting the jigsaw together. International reviews of immunology, 29 (4). pp. 403-20. ISSN 1563-5244