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TAPPred prediction of TAP-binding peptides in antigens.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title TAPPred prediction of TAP-binding peptides in antigens.
 
Creator Bhasin, Manoj
Lata, Sneh
Raghava, G.P.S.
 
Subject QH301 Biology
 
Description The transporter associated with antigen processing (TAP) plays a crucial role in the transport of the peptide fragments of the proteolysed antigenic or self-altered proteins to the endoplasmic reticulum where the association between these peptides and the major histocompatibility complex (MHC) class I molecules takes place. Therefore, prediction of TAP-binding peptides is highly helpful in identifying the MHC class I-restricted T-cell epitopes and hence in the subunit vaccine designing. In this chapter, we describe a support vector machine (SVM)-based method TAPPred that allows users to predict TAP-binding affinity of peptides over web. The server allows user to predict TAP binders using a simple SVM model or cascade SVM model. The server also allows user to customize the display/output. It is freely available for academicians and noncommercial organization at the address http://www.imtech.res.in/raghava/tappred.
 
Publisher Springer Science
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/596/1/raghavaproto1.pdf
Bhasin, Manoj and Lata, Sneh and Raghava, G.P.S. (2007) TAPPred prediction of TAP-binding peptides in antigens. Methods in molecular biology (Clifton, N.J.), 409. pp. 381-6. ISSN 1064-3745
 
Relation http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-60327-118-9_28
http://crdd.osdd.net/open/596/