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PARAMETRIC SENSITIVITY OF STREPTOKINASE FERMENTATION THROUGH MODEL-REDUCTION BY A SEMIEMPIRICAL APPROACH

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title PARAMETRIC SENSITIVITY OF STREPTOKINASE FERMENTATION THROUGH MODEL-REDUCTION BY A SEMIEMPIRICAL APPROACH
 
Creator Patnaik, P R
 
Subject QD Chemistry
 
Description A model comprising five coupled ordinary differential equations describing the fermentative production of streptokinase in a batch reactor was reduced sequentially to one differential equation by introducing two model-based empirical functions. Four key parameters were chosen to study the sensitivity of the model, two parameters reflecting inhibition kinetics and two for decay of active cells and streptokinase. Sensitivities with respect to the inhibition parameters are dominant; perturbations in them show significant differences in the changes in sensitivities with time. These trends, and in particular the start-up profiles, provide useful indications of bioreactor performance.
 
Publisher CHERIC
 
Date 1995
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/701/1/pat95%28s5%29.pdf
Patnaik, P R (1995) PARAMETRIC SENSITIVITY OF STREPTOKINASE FERMENTATION THROUGH MODEL-REDUCTION BY A SEMIEMPIRICAL APPROACH. Hungarian Journal of Industrial Chemistry, 23 (1). pp. 47-53.
 
Relation http://www.cheric.org/research/tech/periodicals/view.php?seq=77906
http://crdd.osdd.net/open/701/