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Novel cellular markers in breast cancer: Differential presence of p23K and p30.33K prosomal antigens in tumors of Parsi and non-Parsi women.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Novel cellular markers in breast cancer: Differential presence of p23K and p30.33K prosomal antigens in tumors of Parsi and non-Parsi women.
 
Creator Bhui, AJ
Bureau, J
Abbas, A
Mondal, A
 
Subject RZ Other systems of medicine
 
Description Epidemiological studies have revealed that Parsi women have a higher incidence of breast cancer than non-Parsis and that they are more susceptible to breast cancer. We have studied the cellular distribution of two prosomal proteins p23K in parallel to the p30.33K and proliferation marker Ki-67 as potential markers to identify high risk population for breast cancers. Flow cytometry data demonstrated that the Parsi benign and non-Parsi malignants have a higher number of cells labelled with these two prosomal protein antibodies than the non-Parsi benign and European 'normals'. Using immunohistochemical methods, p23 K was found to be significantly higher in Parsi and non-Parsi malignants as well as in non-Parsi benigns. In our FCM analysis, intergroup comparison showed, interestingly, a significantly higher expression of both p23K and p30.33K in Parsi benigns as compared to non-Parsis, raising the possibility that benign tumors of Parsis represent already premalignant lesions. The present study, in addition, proposes the prosomal antigens as likely cell proliferation markers comparable to Ki-67.
 
Publisher PROFESSOR D A SPANDIDOS, EDITORIAL OFFICE, 1, S MERKOURI ST, ATHENS 116 35, GREECE
 
Date 1996-10
 
Type Article
PeerReviewed
 
Identifier Bhui, AJ and Bureau, J and Abbas, A and Mondal, A (1996) Novel cellular markers in breast cancer: Differential presence of p23K and p30.33K prosomal antigens in tumors of Parsi and non-Parsi women. INTERNATIONAL JOURNAL OF ONCOLOGY, 9 (4). pp. 669-677. ISSN 1019-6439
 
Relation http://crdd.osdd.net/open/751/