Record Details

Major histocompatibility complex restriction in tuberculosis susceptibility

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title Major histocompatibility complex restriction in tuberculosis susceptibility
 
Creator Pitchappan, R.M.
Agrewala, J N
Dheenadhayalan, V.
Ivanyi, J.
 
Subject QR Microbiology
 
Description More than one mechanism may contribute to disease susceptibility in tuberculosis,
viz., major histocompatability complex (MHC) restriction phenomenon, spectrum of immune
reactivity/cytokine profile and epidemiology induced anergy. Experiments from our laboratories
revealed that (i) human leucocyte antigen D-related allele 2 (HLA DR2) predispose for a more
severe form of pulmonary tuberculosis encoding a high responder status, (ii) spectrum of immune
reactivity to mycobacteria is 'innate', and it is demonstrable in healthy individuals from endemic
area, (iii) there is no correlation between the purified protein derivative (PPD) response and
peptide responses, (iv) once a person is high responder to P16 and P38 derived peptides (6/22),
he/she (whether a patient or control) is a high responder for a wide range of mycobacterial
peptides and (v)majority of the T-cell clones generated in vitro, to peptide 16ยท3 (amino acids
21-40) of 16 kA a mycobacterial antigen, in an HLA DR2 positive healthy individual is HLA DR
restricted, permissive and of Th1 phenotype. The results suggested that MHC class II restriction
play a role in peptide recognition and the immune response. Nonetheless the outcome and
specificity of the immune reactivity and the resultant disease pathogenesis may depend on the
promiscuity of peptide recognition and cytokine profiles.
 
Publisher IAS
 
Date 1997
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/755/1/agrewala1997.1.pdf
Pitchappan, R.M. and Agrewala, J N and Dheenadhayalan, V. and Ivanyi, J. (1997) Major histocompatibility complex restriction in tuberculosis susceptibility. Journal of biosciences, 221. pp. 47-57. ISSN 0250-5991
 
Relation http://www.ias.ac.in/jarch/jbiosci/22/47-57.pdf
http://crdd.osdd.net/open/755/