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Apoptosis of Th1-like cells in experimental tuberculosis (TB)

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Apoptosis of Th1-like cells in experimental tuberculosis (TB)
 
Creator Das, G
Vohra, H
Saha, B
Agrewala, J N
Mishra, G C
 
Subject QR180 Immunology
 
Description Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-γ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.
 
Publisher Wiley
 
Date 1999
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/797/1/agrewala1999.1.pdf
Das, G and Vohra, H and Saha, B and Agrewala, J N and Mishra, G C (1999) Apoptosis of Th1-like cells in experimental tuberculosis (TB). Clinical and Experimental Immunology, 115 (2). pp. 324-328. ISSN 0009-9104
 
Relation http://dx.doi.org/10.1046/j.1365-2249.1999.00755.x
http://crdd.osdd.net/open/797/