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Improvement of the microbial production of streptokinase by controlled filtering of process noise

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Improvement of the microbial production of streptokinase by controlled filtering of process noise
 
Creator Patnaik, P R
 
Subject QD Chemistry
 
Description Disturbances during operation are an ubiquitous feature of large-scale fermentations. This kind of process noise is often describable by a Gaussian distribution and is considered undesirable but unavoidable. In this paper, the fed-batch production of streptokinase (SK) was studied when such disturbances occurred in the inflow rate of the substrate. As the variance of the noise increased upto 6% of the instantaneous value of the flowrate, there was a gradual improvement in the SK activity, after which the activity decreased for larger variances. The peak activity (10 850 U/ml) was 22% higher than for a smooth noise-free feed. Similar earlier observations for β-galactosidase and β-lactamase suggest that normal disturbances may be harnessed to enhance fermentation efficiency by filtering them such that they are maintained within an optimal range.
 
Publisher Elsevier Science
 
Date 1999
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/804/1/patnaik1999.1.pdf
Patnaik, P R (1999) Improvement of the microbial production of streptokinase by controlled filtering of process noise. Process Biochemistry, 35 (3-4). pp. 309-315. ISSN 13595113
 
Relation http://dx.doi.org/10.1016/S0032-9592(99)00073-4
http://crdd.osdd.net/open/804/