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Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates
 
Creator Patnaik, P R
 
Subject QR Microbiology
 
Description When a microbe has a choice of two substrates for its growth in a fermentation medium, its preference varies with the substrates and with time. This "informed" choice is conveniently expressed by cybernetic models. For the growth of Klebsiella oxytoca in a medium of glucose and lactose, a one-parameter cybernetic model of growth has been employed in a batch bioreactor to analyse sensitivity of the fermentation to perturbations in the parameter, ! (0 h ! h 1). The sensitivity surfaces in the (!-time) space show interesting variations which are discussed. An important observation is that while growth is best promoted with !=1, i.e. sequential consumption of the substrates [8], low sensitivities require smaller values of !, i.e. simultaneous utilisation. Thus, in a realistic operation it may be necessary to compromise between high growth (with subsequent high productivity) and low sensitivity.
 
Publisher Springer Science
 
Date 1999
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/808/1/patnaik1999.3.pdf
Patnaik, P R (1999) Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates. Bioprocess Engineering, 21 (2). p. 135. ISSN 0178515X
 
Relation http://dx.doi.org/10.1007/s004490050653
http://crdd.osdd.net/open/808/