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Accelerated proteasomal degradation of membrane Ig heavy chains.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Accelerated proteasomal degradation of membrane Ig heavy chains.
 
Creator Ho, S C
Chaudhuri, Saumya Ray
Bachhawat, Anand K
McDonald, K
Pillai, S
 
Subject QR180 Immunology
 
Description Membrane IgG H chains turn over considerably more rapidly than secretory Ig H chains in the 18-81 A2 pre-B cell line. This rapid degradation occurs in proteasomes. N-Glycosylated membrane Ig H chains accumulate in the endoplasmic reticulum in the presence of proteasomal inhibitors, suggesting that retrotranslocation and proteasomal degradation of membrane Ig H chains may be closely coupled processes. Accelerated proteasomal degradation of membrane Ig H chains was also observed in transfected nonlymphoid cells. At steady state, the membrane form of the H chain associates more readily with Bip and calnexin than its secretory counterpart. The preferential recognition of membrane, as opposed to secretory, Ig H chains by some endoplasmic reticulum chaperones, may provide an explanation for the accelerated proteasomal degradation of the former.
 
Publisher American Association of Immunologists
 
Date 2000-05-01
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/833/1/bachhawat2000.1.pdf
Ho, S C and Chaudhuri, Saumya Ray and Bachhawat, Anand K and McDonald, K and Pillai, S (2000) Accelerated proteasomal degradation of membrane Ig heavy chains. Journal of immunology (Baltimore, Md. : 1950), 164 (9). pp. 4713-9. ISSN 0022-1767
 
Relation http://www.jimmunol.org/content/164/9/4713.long
http://crdd.osdd.net/open/833/