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Mucin antibodies- New tools in diagnosis and therapy of cancer

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Mucin antibodies- New tools in diagnosis and therapy of cancer
 
Creator Uwe , A. Wittel,
Apollina, Goel
Varshney, Grish C
Batra, Surinder K.
 
Subject QR Microbiology
 
Description Many cancer and diseased cells are distinguished
from their normal counterparts by an altered expression of
cell-surface epitopes. One family of molecules that show
altered expression on tumor cells is mucins (MUC). Unlike
normal tissue where MUC exists as heavily glycosylated
form, the disease- or tumor-associated MUC molecules are
underglycosylated. Such underglycosylation of the core
protein in cancer tissues exposes new epitopes on the cell
surface that are unique to cancer tissues. Several
monoclonal antibodies (Mabs) have been generated against
these normal and tumor-associated mucins. Enzymatic
fragments of Mabs like F(ab’)2 and Fab have shown
improved clinical utility for diagnosis, imaging, and
therapy of cancer. Genetic-engineering methods have been
used to design antibody fragments exhibiting high
functional affinity, good tumor localization, and rapid
clearance from the blood stream thus minimizing radiation
exposure to the normal tissues. Such recombinant
fragments have shown encouraging results in preclinical
studies using xenografted tumor bearing mice and present a
whole new avenue for radioimmunotherapy and diagnosis
of cancer.
 
Publisher Bioscience.org
 
Date 2001
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/862/1/varshney2001.pdf
Uwe , A. Wittel, and Apollina, Goel and Varshney, Grish C and Batra, Surinder K. (2001) Mucin antibodies- New tools in diagnosis and therapy of cancer. Frontiers in Bioscience, 6. pp. 1296-1310.
 
Relation http://crdd.osdd.net/open/862/