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External, extrinsic and intrinsic noise in cellular systems: analogies and implications for protein synthesis

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title External, extrinsic and intrinsic noise in cellular systems: analogies and implications for protein synthesis
 
Creator Patnaik, P R
 
Subject QR Microbiology
 
Description Multicellular systems, typically in bioreactors with one or more feed streams, are under the influences
of intrinsic (intra-cellular), extrinsic (inter-cellular) and external (environmental) noise. Of these,
intrinsic noise is relatively less important in determining protein synthesis and reactor behavior.
Although extrinsic noise and external noise have different origins and controls, they have similarities
and interactions. The interactions make it important to control both kinds of noise optimally to enhance
the gene expression of a desired protein, and the similarities enable this to be done. These aspects are
discussed to evolve a comprehensive noise filtering and control strategy for large bioreactors operated
in realistic (noisy) environments.
 
Publisher Academic Journals
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1005/1/patnaik2006.pdf
Patnaik, P R (2006) External, extrinsic and intrinsic noise in cellular systems: analogies and implications for protein synthesis. Biotechnology and Molecular Biology Review, 1 (4). pp. 121-127.
 
Relation http://academicjournals.org/bmbr/PDF/Pdf2006/DEC/Patnaik.pdf
http://crdd.osdd.net/open/1005/