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CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza.
 
Creator Swain, Susan L
Agrewala, J N
Brown, Deborah M
Jelley-Gibbs, Dawn M
Golech, Susanne
Huston, Gail
Jones, Stephen C
Kamperschroer, Cris
Lee, Won-Ha
McKinstry, K Kai
Román, Eulogia
Strutt, Tara
Weng, Nan-ping
 
Subject QR180 Immunology
 
Description We have outlined the carefully orchestrated process of CD4+ T-cell differentiation from naïve to effector and from effector to memory cells with a focus on how these processes can be studied in vivo in responses to pathogen infection. We emphasize that the regulatory factors that determine the quality and quantity of the effector and memory cells generated include (i) the antigen dose during the initial T-cell interaction with antigen-presenting cells; (ii) the dose and duration of repeated interactions; and (iii) the milieu of inflammatory and growth cytokines that responding CD4+ T cells encounter. We suggest that heterogeneity in these regulatory factors leads to the generation of a spectrum of effectors with different functional attributes. Furthermore, we suggest that it is the presence of effectors at different stages along a pathway of progressive linear differentiation that leads to a related spectrum of memory cells. Our studies particularly highlight the multifaceted roles of CD4+ effector and memory T cells in protective responses to influenza infection and support the concept that efficient priming of CD4+ T cells that react to shared influenza proteins could contribute greatly to vaccine strategies for influenza.
 
Publisher wiley
 
Date 2006-06
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1017/1/agrewala2006.1.pdf
Swain, Susan L and Agrewala, J N and Brown, Deborah M and Jelley-Gibbs, Dawn M and Golech, Susanne and Huston, Gail and Jones, Stephen C and Kamperschroer, Cris and Lee, Won-Ha and McKinstry, K Kai and Román, Eulogia and Strutt, Tara and Weng, Nan-ping (2006) CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. Immunological reviews, 211. pp. 8-22. ISSN 0105-2896
 
Relation http://onlinelibrary.wiley.com/doi/10.1111/j.0105-2896.2006.00388.x/abstract
http://crdd.osdd.net/open/1017/