ICAR Research Data Repository for Knowledge Management
Mycobacterial PE_PGRS proteins contain calcium-binding motifs with parallel beta-roll folds.
DIR@IMTECH: CSIR-Institute of Microbial Technology
View Archive Info| Field | Value | |
| Title |
Mycobacterial PE_PGRS proteins contain calcium-binding motifs with parallel beta-roll folds.
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| Creator |
Bachhawat, N
Singh, Balvinder |
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| Subject |
QR Microbiology
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| Description |
The PE_PGRS family of proteins unique to mycobacteria is demonstrated to contain multiple calcium-binding and glycine-rich sequence motifs GGXGXD/NXUX. This sequence repeat constitutes a calcium-binding parallel beta-roll or parallel beta-helix structure and is found in RTX toxins secreted by many Gram-negative bacteria. It is predicted that the highly homologous PE PGRS proteins containing multiple copies of the nona-peptide motif could fold into similar calcium-binding structures. The implication of the predicted calcium-binding property of PE PGRS proteins in the light of macrophage-pathogen interaction and pathogenesis is presented.
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| Publisher |
Science Press
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| Date |
2007-12
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| Type |
Article
PeerReviewed |
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| Identifier |
Bachhawat, N and Singh, Balvinder (2007) Mycobacterial PE_PGRS proteins contain calcium-binding motifs with parallel beta-roll folds. Genomics, proteomics & bioinformatics / Beijing Genomics Institute, 5 (3-4). pp. 236-41. ISSN 1672-0229
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| Relation |
http://crdd.osdd.net/open/1036/
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