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Influence of CD80 and CD86 Co-Stimulation in the Modulation of the Activation of Antigen Presenting Cells

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Influence of CD80 and CD86 Co-Stimulation in the Modulation of the Activation of Antigen Presenting Cells
 
Creator Mir, Manzoor A
Agrewala, J N
 
Subject QR180 Immunology
 
Description The role of CD80 and CD86 costimulatory molecules is well established in the activation of T cells but not antigen presenting cells. Recently, many reports in literature have demonstrated categorically the influence of CD80 and CD86 in the activation of B cells and dendritic cells. Stimulation via CD80/CD86 in B cells can modulate their proliferation, IgG secretion and expression of pro-apoptotic and anti-apoptotic molecules, nuclear localization of NF-κB p50 subunit, phosphorylation of Rel A (p65) and IκB-alpha and increased oct-2 expression. In case of dendritic cells, it has been shown that signals induced via CD80 and CD86 enhance the production of IL-6 and IFN-γ which in turn, upregulates the expression of the enzyme indolamine 2, 3-dioxygenase that results in tryptophan catabolism and affects T cell proliferation. Interestingly, it has been shown that co-stimulation through CD80 can restrict the survival of lymphomas and can also induce apoptosis in neural stem cells. Consequently, it may be concluded that CD28/CD152-CD80/86 interaction delivers a bi-directional co-stimulation, thereby not only having impact on the function of T cells, but also antigen presenting cells
 
Publisher Bentham Science
 
Date 2007
 
Type Article
PeerReviewed
 
Relation http://www.benthamdirect.org/pages/content.php?CIR/2007/00000003/00000003/D0002IR.SGM
http://crdd.osdd.net/open/1042/
 
Identifier Mir, Manzoor A and Agrewala, J N (2007) Influence of CD80 and CD86 Co-Stimulation in the Modulation of the Activation of Antigen Presenting Cells. Current Immunology Reviews, 3 (3). pp. 160-169. ISSN 1875-631X