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Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation
 
Creator Agrewala, J N
Brown, Deborah M
Lepak, M.M.
Duso, D.
Huston, Gail
Swain, S.L.
 
Subject QD Chemistry
 
Description Recent studies suggest that effector T cells generated by
immune responses migrate to multiple non-lymphoid sites,
even those without apparent expression of antigen or inflammation.
To investigate the ability of distinct CD4� T lymphocyte
subsets to enter and persist in non-lymphoid, noninflamed
compartments, we examined the migration and
persistence of naı¨ve, effector, and rested effector CD4� T
cells generated in vitro following transfer to nonimmunized
adoptive hosts. Th1 and Th2 effectors migrated to both
lymphoid and non-lymphoid organs (peritoneum, fat pads,
and lung). In contrast, rested effectors and naı¨ve cells
migrated only to lymphoid areas. Adhesion molecule expression,
but not chemokine receptor expression, correlated with
the ability to enter non-lymphoid sites. Donor cells persisted
longer in lymphoid than in non-lymphoid sites. When hosts
with naı¨ve and memory donor cells were challenged with
antigen, effectors developed in situ, which also migrated to
non-lymphoid sites. Memory cells showed an accelerated
shift to non-lymphoid migration, in keeping with memory
effector formation. These results suggest that only recently
activated effector T cells can disperse to non-lymphoid sites in the absence of antigen and inflammation, and as effectors return to rest, they lose this ability. These data also argue that memory cells in lymphoid sites are longer lived and not in equilibrium with those in non-lymphoid sites.
 
Publisher ASBMB
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1056/1/agrewala2007.pdf
Agrewala, J N and Brown, Deborah M and Lepak, M.M. and Duso, D. and Huston, Gail and Swain, S.L. (2007) Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation. Journal of Biological Chemistry, 282. pp. 6106-6115. ISSN 00219258
 
Relation http://www.jbc.org/content/282/9/6106.full.pdf
http://crdd.osdd.net/open/1056/