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Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44.
 
Creator Chaudhuri, Saumya Ray
Mallam, Joshua N
Chévez-Barrios, Patricia
Wadhwa, Lalita
Ng, Philip
Hurwitz, Mary Y
Hurwitz, Richard L
 
Subject R Medicine (General)
 
Description Adenovirus infection is a significant cause of ocular, respiratory, and gastrointestinal illness and can spread rapidly. Morbidity is considerable in immune-suppressed individuals and there is significant mortality. There are no effective therapies. During preclinical studies of adenoviral-mediated gene therapy for ocular disorders, we noticed a significant increase in transduction when the target cells were exposed to adenovirus in the presence of ocular vitreous. The vitreous is mainly comprised of water, collagen, and the large polysaccharide hyaluronan. In this paper, we report data that implicate hyaluronan in the adenoviral infectious process and show that interference with the interaction between hyaluronan and its cellular receptor CD44 can block adenovirus transduction in vitro and in vivo.
 
Publisher Nature Publishing Group
 
Date 2007-03
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1057/1/saumya2007.pdf
Chaudhuri, Saumya Ray and Mallam, Joshua N and Chévez-Barrios, Patricia and Wadhwa, Lalita and Ng, Philip and Hurwitz, Mary Y and Hurwitz, Richard L (2007) Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44. Molecular therapy : the journal of the American Society of Gene Therapy, 15 (3). pp. 566-70. ISSN 1525-0024
 
Relation http://www.nature.com/mt/journal/v15/n3/pdf/6300044a.pdf
http://crdd.osdd.net/open/1057/