ICAR Research Data Repository for Knowledge Management
Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii
DIR@IMTECH: CSIR-Institute of Microbial Technology
View Archive Info| Field | Value | |
| Title |
Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii
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| Creator |
Srinivasan, V. B.
Rajamohan, Govindan Gebreyes, Wondwossen A |
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| Subject |
QR Microbiology
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| Description |
In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive Escherichia coli host KAM32 resulted in decreased susceptibility to various classes of antimicrobial agents, detergents, and dyes. Deletion of the abeS gene in A. baumannii confirmed its role in conferring resistance to these compounds. |
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| Publisher |
ASM
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://crdd.osdd.net/open/1082/1/rajamohan2009.pdf
Srinivasan, V. B. and Rajamohan, Govindan and Gebreyes, Wondwossen A (2009) Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 53 (12). pp. 5312-5316. ISSN 0066-4804 |
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| Relation |
http://dx.doi.org/10.1128/AAC.00748-09
http://crdd.osdd.net/open/1082/ |
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