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Transient response analysis of the eukaryotic chemosensory system to intra-cellular fluctuations.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Transient response analysis of the eukaryotic chemosensory system to intra-cellular fluctuations.
 
Creator Patnaik, Pratap R
 
Subject QR Microbiology
 
Description Like prokaryotic cells, those of eukaryotes are also subjected to noise from within the cells. While the cells have a built-in mechanism to attenuate the noise, conditions may arise where this is beyond the cell's ability to regulate. Start-up perturbations and those induced by metabolic shifts are examples of such situations. Then, it becomes useful to understand how the cells respond. For a eukaryotic chemosensory system, this has been studied by applying response coefficient analysis to a recent model. With even three dependent variables - an activator, an inhibitor, and a response element - the response coefficients differ widely with time and from one variable to another. These differences are interpreted in terms of the chemosensory mechanism and its robustness. The results complement similar recent studies of Escherichia coli chemotaxis, thus supporting their credibility and versatility.
 
Publisher World Scientific
 
Date 2009-02
 
Type Article
PeerReviewed
 
Relation http://www.worldscinet.com/jbcb/07/0701/S0219720009003960.html
http://crdd.osdd.net/open/1096/
 
Identifier Patnaik, Pratap R (2009) Transient response analysis of the eukaryotic chemosensory system to intra-cellular fluctuations. Journal of bioinformatics and computational biology, 7 (1). pp. 93-105. ISSN 0219-7200