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Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.
 
Creator Kumar, Akhilesh
Tikoo, Shweta
Maity, Shuvadeep
Sengupta, Shantanu
Sengupta, Sagar
Kaur, Amandeep
Kumar Bachhawat, Anand
 
Subject QR Microbiology
 
Description ChaC1 is a mammalian proapoptic protein of unknown function induced during endoplasmic reticulum stress. We show using in vivo studies and novel in vitro assays that the ChaC family of proteins function as γ-glutamyl cyclotransferases acting specifically to degrade glutathione but not other γ-glutamyl peptides. The overexpression of these proteins (but not the catalytically dead E>Q mutants) led to glutathione depletion and enhanced apoptosis in yeast. The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells.
 
Publisher Nature publishing group
 
Date 2012-11-30
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1217/1/bachhawat2012.1.pdf
Kumar, Akhilesh and Tikoo, Shweta and Maity, Shuvadeep and Sengupta, Shantanu and Sengupta, Sagar and Kaur, Amandeep and Kumar Bachhawat, Anand (2012) Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. EMBO reports, 13 (12). pp. 1095-101. ISSN 1469-3178
 
Relation http://www.nature.com/embor/journal/v13/n12/full/embor2012156a.html
http://crdd.osdd.net/open/1217/