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CPPsite: a curated database of cell penetrating peptides.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title CPPsite: a curated database of cell penetrating peptides.
 
Creator Gautam, Ankur
Singh, Harinder
Tyagi, Atul
Chaudhary, Kumardeep
Kumar, Rahul
Kapoor, Pallavi
Raghava, G.P.S.
 
Subject QR Microbiology
 
Description Delivering drug molecules into the cell is one of the major challenges in the process of drug development. In past, cell penetrating peptides have been successfully used for delivering a wide variety of therapeutic molecules into various types of cells for the treatment of multiple diseases. These peptides have unique ability to gain access to the interior of almost any type of cell. Due to the huge therapeutic applications of CPPs, we have built a comprehensive database 'CPPsite', of cell penetrating peptides, where information is compiled from the literature and patents. CPPsite is a manually curated database of experimentally validated 843 CPPs. Each entry provides information of a peptide that includes ID, PubMed ID, peptide name, peptide sequence, chirality, origin, nature of peptide, sub-cellular localization, uptake efficiency, uptake mechanism, hydrophobicity, amino acid frequency and composition, etc. A wide range of user-friendly tools have been incorporated in this database like searching, browsing, analyzing, mapping tools. In addition, we have derived various types of information from these peptide sequences that include secondary/tertiary structure, amino acid composition and physicochemical properties of peptides. This database will be very useful for developing models for predicting effective cell penetrating peptides. Database URL: http://crdd.osdd.net/raghava/cppsite/.
 
Publisher Oxford University Press
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1262/1/raghava2012.2.pdf
Gautam, Ankur and Singh, Harinder and Tyagi, Atul and Chaudhary, Kumardeep and Kumar, Rahul and Kapoor, Pallavi and Raghava, G.P.S. (2012) CPPsite: a curated database of cell penetrating peptides. Database : the journal of biological databases and curation, 2012. bas015. ISSN 1758-0463
 
Relation http://database.oxfordjournals.org/content/2012/bas015.abstract
http://crdd.osdd.net/open/1262/