Record Details

Lipidated promiscuous peptides vaccine for tuberculosis-endemic regions.

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title Lipidated promiscuous peptides vaccine for tuberculosis-endemic regions.
 
Creator Gowthaman, Uthaman
Rai, Pradeep K
Khan, Nargis
Jackson, David C
Agrewala, J N
 
Subject QR180 Immunology
 
Description Despite nine decades of Bacillus Calmette--Guérin (BCG) vaccination, tuberculosis continues to be a major global health challenge. Clinical trials worldwide have proved the inadequacy of the BCG vaccine in preventing the manifestation of pulmonary tuberculosis in adults. Ironically, the efficacy of BCG is poorest in tuberculosis endemic areas. Factors such as nontuberculous or environmental mycobacteria and helminth infestation have been suggested to limit the efficacy of BCG. Hence, in high TB-burden countries, radically novel strategies of vaccination are urgently required. Here we showcase the properties of lipidated promiscuous peptide vaccines that target and activate cells of the innate and adaptive immune systems by employing a Toll-like receptor-2 agonist, S-[2,3-bis(palmitoyloxy)propyl]cysteine (Pam2Cys). Such a strategy elicits robust protection and enduring memory responses by type 1 T helper cells (Th1). Consequently, lipidated peptides may yield a better vaccine than BCG.
 
Publisher Elsevier Science
 
Date 2012-10
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1291/1/agrewala2012.pdf
Gowthaman, Uthaman and Rai, Pradeep K and Khan, Nargis and Jackson, David C and Agrewala, J N (2012) Lipidated promiscuous peptides vaccine for tuberculosis-endemic regions. Trends in molecular medicine, 18 (10). pp. 607-14. ISSN 1471-499X
 
Relation http://www.sciencedirect.com/science/article/pii/S147149141200144X#
http://crdd.osdd.net/open/1291/