ICAR Research Data Repository for Knowledge Management
Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition.
DIR@IMTECH: CSIR-Institute of Microbial Technology
View Archive Info| Field | Value | |
| Title |
Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition.
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| Creator |
Sheokand, Navdeep
Kumar, Santosh Malhotra, Himanshu Tillu, Vikas Raje, Chaaya Iyengar Raje, Manoj |
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| Subject |
QR Microbiology
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| Description |
The long held view is that mammalian cells obtain transferrin (Tf) bound iron utilizing specialized membrane anchored receptors. Here we report that, during increased iron demand, cells secrete the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) which enhances cellular uptake of Tf and iron.
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| Publisher |
Elsevier Science
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| Date |
2013-06
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://crdd.osdd.net/open/1293/1/manojraje13.pdf
Sheokand, Navdeep and Kumar, Santosh and Malhotra, Himanshu and Tillu, Vikas and Raje, Chaaya Iyengar and Raje, Manoj (2013) Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition. Biochimica et biophysica acta, 1830 (6). pp. 3816-27. ISSN 0006-3002 |
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| Relation |
http://www.sciencedirect.com/science/article/pii/S0304416513000974
http://crdd.osdd.net/open/1293/ |
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