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Graphene-gated biochip for the detection of cardiac marker Troponin I.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Graphene-gated biochip for the detection of cardiac marker Troponin I.
 
Creator Tuteja, Satish K
Priyanka,
Bhalla, Vijayender
Deep, Akash
Paul, A K
Suri, C Raman
 
Description We report lithium ion intercalation mediated efficient exfoliation of graphite to form monolithic graphene sheets which have subsequently been investigated for the development of highly sensitive label-free electrochemical detection platform for cardiac biomarker, Troponin I (cTnI). The spectroscopic and morphological analysis demonstrated the formation of defect free graphene sheets which were successfully employed to fabricate an inter-digited microdevice in a drain-source configuration on a silicon biochip. The graphene gated biochip functionalized with anti-cTnI antibodies used in label free detection of cTnI which exhibited an excellent sensitivity in the picogram range (~1 pg mL(-1)) for cTnI without the use of any enzymatic amplification that promises its potential applicability for bio-molecular detection in clinical diagnosis.
 
Publisher Amsterdam : Elsevier
 
Date 2014-01-27
 
Type Article
PeerReviewed
 
Relation http://www.sciencedirect.com/science/article/pii/S0003267013014839
http://crdd.osdd.net/open/1545/
 
Identifier Tuteja, Satish K and Priyanka, and Bhalla, Vijayender and Deep, Akash and Paul, A K and Suri, C Raman (2014) Graphene-gated biochip for the detection of cardiac marker Troponin I. Analytica chimica acta, 809. pp. 148-54. ISSN 1873-4324