ICAR Research Data Repository for Knowledge Management
Caerulomycin A suppresses immunity by inhibiting T cell activity.
DIR@IMTECH: CSIR-Institute of Microbial Technology
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| Title |
Caerulomycin A suppresses immunity by inhibiting T cell activity.
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| Creator |
Singla, Arvind K
Gurram, Rama Krishna Chauhan, Arun Khatri, Neeraj Vohra, Rakesh M Jolly, R S Agrewala, J N |
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| Description |
Caerulomycin A (CaeA) is a known antifungal and antibiotic agent. Further, CaeA is reported to induce the expansion of regulatory T cell and prolongs the survival of skin allografts in mouse model of transplantation. In the current study, CaeA was purified and characterized from a novel species of actinomycetes, Actinoalloteichus spitiensis. The CaeA was identified for its novel immunosuppressive property by inhibiting in vitro and in vivo function of T cells.
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| Publisher |
San Francisco, CA : Public Library of Science
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| Date |
2014
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| Type |
Article
PeerReviewed |
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| Relation |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107051
http://crdd.osdd.net/open/1564/ |
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| Identifier |
Singla, Arvind K and Gurram, Rama Krishna and Chauhan, Arun and Khatri, Neeraj and Vohra, Rakesh M and Jolly, R S and Agrewala, J N (2014) Caerulomycin A suppresses immunity by inhibiting T cell activity. PloS one, 9 (10). e107051. ISSN 1932-6203
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