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NPACT: Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title NPACT: Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database.
 
Creator Mangal, Manu
Sagar, Parul
Singh, Harinder
Raghava, G.P.S.
Agarwal, Subhash M
 
Description Plant-derived molecules have been highly valued by biomedical researchers and pharmaceutical companies for developing drugs, as they are thought to be optimized during evolution. Therefore, we have collected and compiled a central resource Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database (NPACT, http://crdd.osdd.net/raghava/npact/) that gathers the information related to experimentally validated plant-derived natural compounds exhibiting anti-cancerous activity (in vitro and in vivo), to complement the other databases. It currently contains 1574 compound entries, and each record provides information on their structure, manually curated published data on in vitro and in vivo experiments along with reference for users referral, inhibitory values (IC(50)/ED(50)/EC(50)/GI(50)), properties (physical, elemental and topological), cancer types, cell lines, protein targets, commercial suppliers and drug likeness of compounds. NPACT can easily be browsed or queried using various options, and an online similarity tool has also been made available. Further, to facilitate retrieval of existing data, each record is hyperlinked to similar databases like SuperNatural, Herbal Ingredients' Targets, Comparative Toxicogenomics Database, PubChem and NCI-60 GI(50) data.
 
Publisher 1992- : Oxford : Oxford University Press
 
Date 2013-01
 
Type Article
PeerReviewed
 
Relation http://nar.oxfordjournals.org/content/41/D1/D1124.long
http://crdd.osdd.net/open/1593/
 
Identifier Mangal, Manu and Sagar, Parul and Singh, Harinder and Raghava, G.P.S. and Agarwal, Subhash M (2013) NPACT: Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database. Nucleic acids research, 41 (Databa). D1124-9. ISSN 1362-4962