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Cooperation of CD86 signaling with TLR-2 in the activation of resting B cells: a novel BCR independent pathway of stimulating B cells (P1126)

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Cooperation of CD86 signaling with TLR-2 in the activation of resting B cells: a novel BCR independent pathway of stimulating B cells (P1126)
 
Creator Chodisetti, Sathi Babu
Jain, Shweta
Agrewala, J N
 
Description The molecules of adaptive and innate immunity cooperate with each other in inducing effective immune response. It is well established fact that B cells can be activated through BCR mediated signaling. Here, we report an alternative strategy of activating resting B cells (RB cells) through concurrent engagement of CD86 and Toll like receptor-2. Concomitant signaling through CD86 and TLR-2 significantly augmented the longevity and activation profile of RB cells. Further, these cells showed enhanced pinocytosis and receptor mediated endocytosis. Furthermore, these cells secreted high levels of IgM and IgG1 and showed better ratio of surface IgG/IgM. Moreover, this process of activation amplifies the population of marginal zone precursors, which connect innate and adaptive arms of immune response. There was also upregulation of set of genes involved in the B cell activation, proliferation, maturation and endocytosis. The data are well in agreement with the gene expression profiles and insinuates to further decipher the molecular mechanism behind this concurrence. An insight into the detailed mechanism may pave way to design vaccines based on this signaling strategy.
 
Publisher American Association of Immunologists, Inc.
 
Date 2013
 
Type Article
PeerReviewed
 
Relation http://www.jimmunol.org/cgi/content/meeting_abstract/190/1_MeetingAbstracts/64.10
http://crdd.osdd.net/open/1596/
 
Identifier Chodisetti, Sathi Babu and Jain, Shweta and Agrewala, J N (2013) Cooperation of CD86 signaling with TLR-2 in the activation of resting B cells: a novel BCR independent pathway of stimulating B cells (P1126). Journal of Immunology, 190.