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Transcription factors and cognate signalling cascades in the regulation of autophagy.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Transcription factors and cognate signalling cascades in the regulation of autophagy.
 
Creator Chandra, Vemika
Bhagyaraj, Ella
Parkesh, Raman
Gupta, Pawan
 
Subject QR Microbiology
 
Description Autophagy is a process that maintains the equilibrium between biosynthesis and the recycling of cellular constituents; it is critical for avoiding the pathophysiology that results from imbalance in cellular homeostasis. Recent reports indicate the need for the design of high-throughput screening assays to identify targets and small molecules for autophagy modulation. For such screening, however, a better understanding of the regulation of autophagy is essential. In addition to regulation by various signalling cascades, regulation of gene expression by transcription factors is also critical. This review focuses on the various transcription factors as well as the corresponding signalling molecules that act together to translate the stimuli to effector molecules that up- or downregulate autophagy. This review rationalizes the importance of these transcription factors functioning in tandem with cognate signalling molecules and their interfaces as possible therapeutic targets for more specific pharmacological interventions.
 
Publisher Wiley
 
Date 2015-02-04
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1663/1/Pawan%20Gupta%202015%20Biol%20Rev%20Camb%20Philos%20Soc%20brv12177.pdf
Chandra, Vemika and Bhagyaraj, Ella and Parkesh, Raman and Gupta, Pawan (2015) Transcription factors and cognate signalling cascades in the regulation of autophagy. Biological reviews of the Cambridge Philosophical Society. ISSN 1469-185X
 
Relation http://onlinelibrary.wiley.com/doi/10.1111/brv.12177/pdf
http://crdd.osdd.net/open/1663/