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VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets.
 
Creator Qureshi, Abid
Thakur, Nishant
Monga, Isha
Thakur, Anamika
Kumar, Manoj
 
Subject QR Microbiology
 
Description Viral microRNAs (miRNAs) regulate gene expression of viral and/or host genes to benefit the virus. Hence, miRNAs play a key role in host-virus interactions and pathogenesis of viral diseases. Lately, miRNAs have also shown potential as important targets for the development of novel antiviral therapeutics. Although several miRNA and their target repositories are available for human and other organisms in literature, but a dedicated resource on viral miRNAs and their targets are lacking. Therefore, we have developed a comprehensive viral miRNA resource harboring information of 9133 entries in three subdatabases. This includes 1308 experimentally validated miRNA sequences with their isomiRs encoded by 44 viruses in viral miRNA ' VIRMIRNA: ' and 7283 of their target genes in ' VIRMIRTAR': . Additionally, there is information of 542 antiviral miRNAs encoded by the host against 24 viruses in antiviral miRNA ' AVIRMIR': . The web interface was developed using Linux-Apache-MySQL-PHP (LAMP) software bundle. User-friendly browse, search, advanced search and useful analysis tools are also provided on the web interface. VIRmiRNA is the first specialized resource of experimentally proven virus-encoded miRNAs and their associated targets. This database would enhance the understanding of viral/host gene regulation and may also prove beneficial in the development of antiviral therapeutics. Database URL: http://crdd.osdd.net/servers/virmirna.
 
Publisher Oxford University Press
 
Date 2014
 
Type Article
PeerReviewed
 
Relation http://database.oxfordjournals.org/content/2014/bau103.long
http://crdd.osdd.net/open/1678/
 
Identifier Qureshi, Abid and Thakur, Nishant and Monga, Isha and Thakur, Anamika and Kumar, Manoj (2014) VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets. Database : the journal of biological databases and curation, 2014. ISSN 1758-0463