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Sphingolipid biosynthetic pathway genes FEN1 and SUR4 modulate amphotericin B resistance.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Sphingolipid biosynthetic pathway genes FEN1 and SUR4 modulate amphotericin B resistance.
 
Creator Sharma, Sushma
Alfatah, Md
Bari, Vinay K
Rawal, Yashpal
Paul, Sanjoy
Ganesan, K
 
Subject QR Microbiology
 
Description Deletants of the sphingolipid biosynthetic pathway genes FEN1 and SUR4 of Saccharomyces cerevisiae, as well as deletants of their orthologs in Candida albicans, were found to be 2- to 5-fold-more sensitive to amphotericin B (AmB) than parent strains. The inhibition of sphingolipid biosynthesis in parent strains by myriocin sensitized them to AmB, which can be reversed by providing phytosphingosine, an intermediate in the sphingolipid pathway. These results indicate that sphingolipids modulate AmB resistance, with implications for mechanisms underlying AmB action and resistance.
 
Publisher ASM
 
Date 2014
 
Type Article
PeerReviewed
 
Relation http://aac.asm.org/content/58/4/2409.long
http://crdd.osdd.net/open/1701/
 
Identifier Sharma, Sushma and Alfatah, Md and Bari, Vinay K and Rawal, Yashpal and Paul, Sanjoy and Ganesan, K (2014) Sphingolipid biosynthetic pathway genes FEN1 and SUR4 modulate amphotericin B resistance. Antimicrobial agents and chemotherapy, 58 (4). pp. 2409-14. ISSN 1098-6596