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CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides.
 
Creator Agrawal, Piyush
Bhalla, Sherry
Usmani, Salman Sadullah
Singh, Sandeep
Chaudhary, Kumardeep
Raghava, G.P.S.
Gautam, Ankur
 
Subject QR Microbiology
 
Description CPPsite 2.0 (http://crdd.osdd.net/raghava/cppsite/) is an updated version of manually curated database (CPPsite) of cell-penetrating peptides (CPPs). The current version holds around 1850 peptide entries, which is nearly two times than the entries in the previous version. The updated data were curated from research papers and patents published in last three years. It was observed that most of the CPPs discovered/ tested, in last three years, have diverse chemical modifications (e.g. non-natural residues, linkers, lipid moieties, etc.). We have compiled this information on chemical modifications systematically in the updated version of the database. In order to understand the structure-function relationship of these peptides, we predicted tertiary structure of CPPs, possessing both modified and natural residues, using state-of-the-art techniques. CPPsite 2.0 also maintains information about model systems (in vitro/in vivo) used for CPP evaluation and different type of cargoes (e.g. nucleic acid, protein, nanoparticles, etc.) delivered by these peptides. In order to assist a wide range of users, we developed a user-friendly responsive website, with various tools, suitable for smartphone, tablet and desktop users. In conclusion, CPPsite 2.0 provides significant improvements over the previous version in terms of data content.
 
Publisher Oxford University Press
 
Date 2016-01-04
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1739/1/3.pdf
Agrawal, Piyush and Bhalla, Sherry and Usmani, Salman Sadullah and Singh, Sandeep and Chaudhary, Kumardeep and Raghava, G.P.S. and Gautam, Ankur (2016) CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides. Nucleic acids research, 44 (D1). D1098-103. ISSN 1362-4962
 
Relation http://nar.oxfordjournals.org/content/44/D1/D1098.long
http://crdd.osdd.net/open/1739/