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Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines.
 
Creator Singh, Harinder
Gupta, Sudheer
Gautam, Ankur
Raghava, G.P.S.
 
Subject QR Microbiology
 
Description Rationally designed subunit vaccines mainly consist of small peptides or B-cell epitopes, which can stimulate the body's immune response. Development of subunit vaccines is a very tedious and costly process. One of the imperative and crucial steps of vaccine development is the identification of highly competent B-cell epitopes as most of the proteins and fragments of proteins are immunologically irrelevant. With the advances in bioinformatics tools, it can be possible to precisely narrow down potential B-cell epitopes from the whole proteome of any pathogen. This chapter sheds light on prediction and designing of B-cell epitopes using two in silico tools LBtope and IgPred.
 
Publisher Springer
 
Date 2015
 
Type Article
PeerReviewed
 
Relation http://link.springer.com/protocol/10.1007%2F978-1-4939-2999-3_28
http://crdd.osdd.net/open/1751/
 
Identifier Singh, Harinder and Gupta, Sudheer and Gautam, Ankur and Raghava, G.P.S. (2015) Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines. Methods in molecular biology (Clifton, N.J.), 1348. pp. 327-40. ISSN 1940-6029