A highly efficient designer cell for enantioselective reduction of ketones
DIR@IMTECH: CSIR-Institute of Microbial Technology
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Title |
A highly efficient designer cell for enantioselective reduction of ketones
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Creator |
Srivastava, Gautam
Pal, Mohan Kaur, Suneet Jolly, R S |
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Subject |
QD Chemistry
QR Microbiology |
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Description |
A designer cell, surf-crs-gdh, coexpressing carbonyl reductase (crs) and glucose dehydrogenase (gdh) on the cell surface has been constructed and its enzyme activities are compared with those of the corresponding cell, cyto-crs-gdh, coexpressing crs and gdh in cytosol. For various ketones, surf-crs-gdh exhibited 48- to 265-fold higher crs activity per unit protein compared to cyto-crs-gdh.
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Publisher |
Royal Society of Chemistry
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Date |
2015
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Type |
Article
PeerReviewed |
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Relation |
http://dx.doi.org/10.1039/C4CY01017E
http://crdd.osdd.net/open/1781/ |
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Identifier |
Srivastava, Gautam and Pal, Mohan and Kaur, Suneet and Jolly, R S (2015) A highly efficient designer cell for enantioselective reduction of ketones. Catalysis Science & Technology, 5 (1). pp. 105-108. ISSN 2044-4753
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