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SATPdb: a database of structurally annotated therapeutic peptides

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title SATPdb: a database of structurally annotated therapeutic peptides
 
Creator Singh, Sandeep
Chaudhary, Kumardeep
Dhanda, Sandeep Kumar
Bhalla, Sherry
Usmani, Salman Sadullah
Gautam, Ankur
Tuknait, Abhishek
Agrawal, Piyush
Mathur, Deepika
Raghava, G.P.S.
 
Subject QR Microbiology
 
Description SATPdb (http://crdd.osdd.net/raghava/satpdb/) is a database of structurally annotated therapeutic peptides, curated from 22 public domain peptide databases/datasets including 9 of our own. The current version holds 19192 unique experimentally validated therapeutic peptide sequences having length between 2 and 50 amino acids. It covers peptides having natural, non-natural and modified residues. These peptides were systematically grouped into 10 categories based on their major function or therapeutic property like 1099 anticancer, 10585 antimicrobial, 1642 drug delivery and 1698 antihypertensive peptides. We assigned or annotated structure of these therapeutic peptides using structural databases (Protein Data Bank) and state-of-the-art structure prediction methods like I-TASSER, HHsearch and PEPstrMOD. In addition, SATPdb facilitates users in performing various tasks that include: (i) structure and sequence similarity search, (ii) peptide browsing based on their function and properties, (iii) identification of moonlighting peptides and (iv) searching of peptides having desired structure and therapeutic activities. We hope this database will be useful for researchers working in the field of peptide-based therapeutics.
 
Publisher Oxford University Press
 
Date 2015
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.1093/nar/gkv1114
http://crdd.osdd.net/open/1824/
 
Identifier Singh, Sandeep and Chaudhary, Kumardeep and Dhanda, Sandeep Kumar and Bhalla, Sherry and Usmani, Salman Sadullah and Gautam, Ankur and Tuknait, Abhishek and Agrawal, Piyush and Mathur, Deepika and Raghava, G.P.S. (2015) SATPdb: a database of structurally annotated therapeutic peptides. Nucleic Acids Research, 44 (D1). D1119-D1126. ISSN 0305-1048