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Cell-penetrating peptide and antibiotic combination therapy: a potential alternative to combat drug resistance in methicillin-resistant Staphylococcus aureus.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Cell-penetrating peptide and antibiotic combination therapy: a potential alternative to combat drug resistance in methicillin-resistant Staphylococcus aureus.
 
Creator Randhawa, Harmandeep Kaur
Gautam, Ankur
Sharma, Minakshi
Bhatia, Rakesh
Varshney, Grish C
Raghava, G.P.S.
Nandanwar, Hemraj
 
Subject QR Microbiology
 
Description The diverse pattern of resistance by methicillin-resistant Staphylococcus aureus (MRSA) is the major obstacle in the treatment of its infections. The key reason of resistance is the poor membrane permeability of drug molecules. Over the last decade, cell-penetrating peptides (CPPs) have emerged as efficient drug delivery vehicles and have been exploited to improve the intracellular delivery of numerous therapeutic molecules in preclinical studies. Therefore, to overcome the drug resistance, we have investigated for the first time the effects of two CPPs (P3 and P8) in combination with four antibiotics (viz. oxacillin, erythromycin, norfloxacin, and vancomycin) against MRSA strains. We found that both CPPs internalized into the MRSA efficiently at very low concentration (
 
Publisher Springer
 
Date 2016-03
 
Type Article
PeerReviewed
 
Relation http://link.springer.com/article/10.1007%2Fs00253-016-7329-7
http://crdd.osdd.net/open/1834/
 
Identifier Randhawa, Harmandeep Kaur and Gautam, Ankur and Sharma, Minakshi and Bhatia, Rakesh and Varshney, Grish C and Raghava, G.P.S. and Nandanwar, Hemraj (2016) Cell-penetrating peptide and antibiotic combination therapy: a potential alternative to combat drug resistance in methicillin-resistant Staphylococcus aureus. Applied microbiology and biotechnology, 100 (9). pp. 4073-4083. ISSN 1432-0614