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Genomic investigation reveals evolution and lifestyle adaptation of endophytic Staphylococcus epidermidis.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Genomic investigation reveals evolution and lifestyle adaptation of endophytic Staphylococcus epidermidis.
 
Creator Chaudhry, Vasvi
Patil, Prabhu B
 
Subject QR Microbiology
 
Description Staphylococcus epidermidis is a major human associated bacterium and also an emerging nosocomial pathogen. There are reports of its association to rodents, sheep and plants. However, comparative and evolutionary studies of ecologically diverse strains of S. epidermidis are lacking. Here, we report the whole genome sequences of four S. epidermidis strains isolated from surface sterilized rice seeds along with genome sequence of type strain. Phylogenomic analysis of rice endophytic S. epidermidis (RESE) with "type strain" unequivocally established their species identity. Whole genome based tree of 93 strains of S. epidermidis revealed RESE as distinct sub-lineage which is more related to rodent sub-lineage than to majority of human lineage strains. Furthermore, comparative genomics revealed 20% variable gene-pool in S. epidermidis, suggesting that genomes of ecologically diverse strains are under flux. Interestingly, we were also able to map several genomic regions that are under flux and gave rise to RESE strains. The largest of these genomic regions encodes a cluster of genes unique to RESE that are known to be required for survival and stress tolerance, apart from those required for adaptation to plant habitat. The genomes and genes of RESE represent distinct ecological resource/sequences and provided first evolutionary insights into adaptation of S. epidermidis to plants.
 
Publisher NPG
 
Date 2016
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1840/1/17.pdf
Chaudhry, Vasvi and Patil, Prabhu B (2016) Genomic investigation reveals evolution and lifestyle adaptation of endophytic Staphylococcus epidermidis. Scientific reports, 6. p. 19263. ISSN 2045-2322
 
Relation http://www.nature.com/articles/srep19263
http://crdd.osdd.net/open/1840/