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ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.
 
Creator Gupta, Amit Kumar
Kaur, Karambir
Rajput, Akanksha
Dhanda, Sandeep Kumar
Sehgal, Manika
Khan, Md Shoaib
Monga, Isha
Dar, Showkat Ahmad
Singh, Sandeep
Nagpal, Gandharva
Usmani, Salman Sadullah
Thakur, Anamika
Kaur, Gazaldeep
Sharma, Shivangi
Bhardwaj, Aman
Qureshi, Abid
Raghava, G.P.S.
Kumar, Manoj
 
Subject QR Microbiology
 
Description Current Zika virus (ZIKV) outbreaks that spread in several areas of Africa, Southeast Asia, and in pacific islands is declared as a global health emergency by World Health Organization (WHO). It causes Zika fever and illness ranging from severe autoimmune to neurological complications in humans. To facilitate research on this virus, we have developed an integrative multi-omics platform; ZikaVR (http://bioinfo.imtech.res.in/manojk/zikavr/), dedicated to the ZIKV genomic, proteomic and therapeutic knowledge. It comprises of whole genome sequences, their respective functional information regarding proteins, genes, and structural content. Additionally, it also delivers sophisticated analysis such as whole-genome alignments, conservation and variation, CpG islands, codon context, usage bias and phylogenetic inferences at whole genome and proteome level with user-friendly visual environment. Further, glycosylation sites and molecular diagnostic primers were also analyzed. Most importantly, we also proposed potential therapeutically imperative constituents namely vaccine epitopes, siRNAs, miRNAs, sgRNAs and repurposing drug candidates.
 
Publisher NPG
 
Date 2016
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1869/1/28.pdf
Gupta, Amit Kumar and Kaur, Karambir and Rajput, Akanksha and Dhanda, Sandeep Kumar and Sehgal, Manika and Khan, Md Shoaib and Monga, Isha and Dar, Showkat Ahmad and Singh, Sandeep and Nagpal, Gandharva and Usmani, Salman Sadullah and Thakur, Anamika and Kaur, Gazaldeep and Sharma, Shivangi and Bhardwaj, Aman and Qureshi, Abid and Raghava, G.P.S. and Kumar, Manoj (2016) ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis. Scientific reports, 6. p. 32713. ISSN 2045-2322
 
Relation http://www.nature.com/articles/srep32713
http://crdd.osdd.net/open/1869/