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SigMol: repertoire of quorum sensing signaling molecules in prokaryotes.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title SigMol: repertoire of quorum sensing signaling molecules in prokaryotes.
 
Creator Rajput, Akanksha
Kaur, Karambir
Kumar, Manoj
 
Subject QR Microbiology
 
Description Quorum sensing is a widespread phenomenon in prokaryotes that helps them to communicate among themselves and with eukaryotes. It is driven through quorum sensing signaling molecules (QSSMs) in a density dependent manner that assists in numerous biological functions like biofilm formation, virulence factors secretion, swarming motility, bioluminescence, etc. Despite immense implications, dedicated resources of QSSMs are lacking. Therefore, we have developed SigMol (http://bioinfo.imtech.res.in/manojk/sigmol), a specialized repository of these molecules in prokaryotes. SigMol harbors information on QSSMs pertaining to different quorum sensing signaling systems namely acylated homoserine lactones (AHLs), diketopiperazines (DKPs), 4-hydroxy-2-alkylquinolines (HAQs), diffusible signal factors (DSFs), autoinducer-2 (AI-2) and others. Database contains 1382: entries of 182: unique signaling molecules from 215: organisms. It encompasses biological as well as chemical aspects of signaling molecules. Biological information includes genes, preliminary bioassays, identification assays and applications, while chemical detail comprises of IUPAC name, SMILES and structure. We have provided user-friendly browsing and searching facilities for easy data retrieval and comparison. We have gleaned information of diverse QSSMs reported in literature at a single platform 'SigMol'. This comprehensive resource will assist the scientific community in understanding intraspecies, interspecies or interkingdom networking and further help to unfold different facets of quorum sensing and related therapeutics.
 
Publisher OUP
 
Date 2016-01-04
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/1921/1/Nucl.%20Acids%20Res.-2016-Rajput-D634-9.pdf
Rajput, Akanksha and Kaur, Karambir and Kumar, Manoj (2016) SigMol: repertoire of quorum sensing signaling molecules in prokaryotes. Nucleic acids research, 44 (D1). D634-9. ISSN 1362-4962
 
Relation http://nar.oxfordjournals.org/content/44/D1/D634.full.pdf+html
http://crdd.osdd.net/open/1921/