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An atypical segment swap in the DN and DC domains of the Acr_tran family resistance-nodulation-cell division pump

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title An atypical segment swap in the DN and DC domains of the Acr_tran family resistance-nodulation-cell division pump
 
Creator Acharya, Giriraj
Kaur, Gurmeet
Subramanian, Srikrishna
 
Subject QH426 Genetics
 
Description Domain/segment swapping is an exchange of equivalent secondary structure element(s) among two or more protein domains resulting in the reconstitution of the original fold while simultaneously causing oligomerization. Here we report an example of the outer membrane factor docking region of the Acr_tran family (PF00873) resistance-nodulation-cell division pump, in which a swapped, misfolded state, of the ferredoxin-like fold of the DN and DC domains, effectuates oligomerization. The atypical segment swap and the associated displacement of a region of the ferredoxin-like fold leads to a topology that is distinct from the original fold. To our knowledge, such segment swaps and associated fold change are rare. This exemplifies the role of functional constraints including oligomerization that determine the interplay between sequence and the three-dimensional structure of proteins.
 
Date 2016
 
Type Article
PeerReviewed
 
Relation http://dx.doi.org/10.1016/j.jsb.2016.08.004
http://crdd.osdd.net/open/1927/
 
Identifier Acharya, Giriraj and Kaur, Gurmeet and Subramanian, Srikrishna (2016) An atypical segment swap in the DN and DC domains of the Acr_tran family resistance-nodulation-cell division pump. Journal of Structural Biology, 196 (3). pp. 358-363. ISSN 10478477