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Frequency and genotype distribution of ABCB1 gene polymorphisms among Maharashtrian population of Central India

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Title Frequency and genotype distribution of ABCB1 gene polymorphisms among Maharashtrian population of Central India
 
Creator Pramanik, Sreemanta
Surendran, Subin T
Saravana Devi, S
Krishnamurthi, Kannan
Chakrabarti, T
 
Subject Environmental Health
 
Description 1. Apart from conferring multidrug resistance to cancer cells, P-glycoprotein (P-gp) encoded by
the gene ABCB1 (also, known as Multidrug resistance gene, MDR1), plays a major role in drug
disposition. Single nucleotide polymorphisms (SNPs) in the ABCB1 gene might contribute to
inter-individual and ethnic differences in drug disposition and thereby, could influence the
outcome and prognosis of certain diseases.
2. India is one of the most ethnically and genetically diverse regions of the world. This study
was undertaken with a view to determine the allele and genotype frequencies of C3435T
and C1236T polymorphisms in the ABCB1 gene among the Maharshtrian population,
residing in the Vidarbha region of central India and compare them with HapMap and other
Indian populations. The common synonymous C3435T polymorphism has been found to be
associated with lower P-gp functional expression and drug uptake, alone or in conjunction
with a few other linked SNPs like C1236T.
3. The genotypes of C3435T and C1236T SNPs were determined by PCR-RFLP in 222 healthy
and unrelated Maharashtrian individuals.
4. According to the findings of this study, the Maharashtrians were found to be not
significantly different from the Gujarati Indians in Houston, Texas in the HapMap database.
 
Publisher Informa Healthcare
 
Date 2014-06
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/493/1/SreemantaXenobiotica_2013.pdf
Pramanik, Sreemanta and Surendran, Subin T and Saravana Devi, S and Krishnamurthi, Kannan and Chakrabarti, T (2014) Frequency and genotype distribution of ABCB1 gene polymorphisms among Maharashtrian population of Central India. Xenobiotica, 44 (6). pp. 579-582. ISSN 0049-8254 (Print) 1366-5928 (Electronic)
 
Relation http://informahealthcare.com/toc/xen/44/6
http://neeri.csircentral.net/493/