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Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity

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Title Potential Role of Epigenetic Mechanism in
Manganese Induced Neurotoxicity
 
Creator Tarale, Prashant
Chakrabarti, Tapan
Sivanesan, Saravanadevi
Naoghare, Pravin
Bafana, Amit
Krishnamurthi, Kannan
 
Subject Environmental Health
 
Description Manganese is a vital nutrient and is maintained at an optimal level (2.5–5 mg/day) in human body. Chronic exposure to manganese
is associated with neurotoxicity and correlated with the development of various neurological disorders such as Parkinson’s disease.
Oxidative stress mediated apoptotic cell death has been well established mechanism in manganese induced toxicity. Oxidative stress
has a potential to alter the epigenetic mechanism of gene regulation. Epigenetic insight of manganese neurotoxicity in context of
its correlation with the development of parkinsonism is poorly understood. Parkinson’s disease is characterized by the �-synuclein
aggregation in the form of Lewy bodies in neuronal cells. Recent fndings illustrate that manganese can cause overexpression of
�-synuclein. �-Synuclein acts epigenetically via interaction with histone proteins in regulating apoptosis. �-Synuclein also causes
global DNA hypomethylation through sequestration of DNA methyltransferase in cytoplasm. An individual genetic difference
may also have an influence on epigenetic susceptibility to manganese neurotoxicity and the development of Parkinson’s disease.
Tis review presents the current state of fndings in relation to role of epigenetic mechanism in manganese induced neurotoxicity,
with a special emphasis on the development of Parkinson’s disease.
 
Publisher Hindawi Publishing Corporation
 
Date 2016
 
Type Article
NonPeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/753/1/Review%20Manganese.pdf
Tarale, Prashant and Chakrabarti, Tapan and Sivanesan, Saravanadevi and Naoghare, Pravin and Bafana, Amit and Krishnamurthi, Kannan (2016) Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity. BioMed Research International. pp. 1-18. ISSN 2314-6133, ESSN: 2314-6141
 
Relation https://www.hindawi.com/journals/bmri/2016/2548792/abs/
http://neeri.csircentral.net/753/