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Investigation of Immune Biomarkers Using Subcutaneous Model of M. tuberculosis Infection in BALB/c Mice: A Preliminary Report

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Title Investigation of Immune Biomarkers Using Subcutaneous
Model of M. tuberculosis Infection in BALB/c Mice:
A Preliminary Report
 
Creator Husain, Aliabbas A
Daginawala, Hatim F
Warke, Shubangi R
Kalorey, Devanand R
Kurkure, Nitin V
Purohit, H J
Taori, Girdhar M
Kashyap, Rajpal S
 
Subject Microbiology
 
Description Evaluation and screening of vaccines against tuberculosis
depends on development of proper cost effective disease
models along with identification of different immune markers
that can be used as surrogate endpoints of protection in preclinical
and clinical studies. The objective of the present
study was therefore evaluation of subcutaneous model of
M.tuberculosis infection along with investigation of different
immune biomarkers of tuberculosis infection in BALB/c
mice. Groups of mice were infected subcutaneously with two
different doses : high (2×106
CFU) and low doses (2×102
CFU) of M.tuberculosis and immune markers including humoral
and cellular markers were evaluated 30 days post
M.tuberculosis infections. Based on results, we found that
high dose of subcutaneous infection produced chronic disease
with significant (p
 
Publisher Korean Association of Immunologists
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/819/1/husain%202015.pdf
Husain, Aliabbas A and Daginawala, Hatim F and Warke, Shubangi R and Kalorey, Devanand R and Kurkure, Nitin V and Purohit, H J and Taori, Girdhar M and Kashyap, Rajpal S (2015) Investigation of Immune Biomarkers Using Subcutaneous Model of M. tuberculosis Infection in BALB/c Mice: A Preliminary Report. Immune Network, 15 (2). pp. 83-90. ISSN 1598-2629, ESSN: 2092-6685
 
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http://neeri.csircentral.net/819/