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Molecular diagnosis of leishmaniasis at the subgenus and species level

IR@CSIR-NEERI

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Title Molecular diagnosis of leishmaniasis at the subgenus
and species level
 
Creator Khairnar, Krishna
Lynde, Carrie
Keystone , Jay
Ralevski, Filip
McCarthy , Anne
Levine , Jeremy
Pillai, Dylan R.
 
Subject Microbiology
 
Description We report three cases of imported cutaneous leishmaniasis
in Canada. The current diagnostic modalities such as
culture and histopathology demand expertise and are time
consuming. We adapted a rapid molecular diagnostic method
like real-time PCR (RT-PCR) for leishmaniasis, which enabled
speciation not possible by traditional culture methods.
Based on the findings of RT-PCR, the management of cutaneous
leishmaniasis caused by Leishmania (Leishmania )
tropica may be done with a conservative approach; an aggressive
treatment approach may be adapted for management
of cutaneous leishmaniasis caused by Leishmania (Viannia)
panamensis especially considering the potential risk of
Leishmania Viannia complex causing mucocutaneous leishmaniasis.
The RT-PCR assay described here enables the speciation
of Leishmania, which may be useful to the clinical
management of leishmaniasis in returning travelers.
 
Publisher Springer
 
Date 2016
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/833/1/Publication_17.pdf
Khairnar, Krishna and Lynde, Carrie and Keystone , Jay and Ralevski, Filip and McCarthy , Anne and Levine , Jeremy and Pillai, Dylan R. (2016) Molecular diagnosis of leishmaniasis at the subgenus and species level. Parasitology Research, 115 (1). p. 49. ISSN 0932-0113, ESSN: 1432-1955
 
Relation https://link.springer.com/journal/436
http://neeri.csircentral.net/833/