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DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 loci in Maharashtrian population of central India

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Title DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 loci in Maharashtrian population of central India
 
Creator Pramanik, Sreemanta
Devi, Saravana
Surendran, Subin
Chowdhary, Sanghamitra
Krishnamurthi, Kannan
Chakrabarti, Tapan
 
Subject Environmental Biotechnology
Environmental Health
 
Description Reduction in DNA repair capacity is associated with increased rates of birth defects, cancer, and accelerated
ageing. Genetic polymorphisms in DNA repair genes might influence the repair activities of the
enzymes predisposing individuals to cancer risk. Owing to the presence of these genetic variants,
inter-individual and ethnic differences in DNA repair capacity have been observed in various populations.
India harbors enormous genetic, cultural and linguistic diversity. The present study was undertaken to
determine the allele and genotype frequencies of four non-synonymous SNPs, XRCC1 Arg399Gln (C > T,
rs25487), XRCC3 Thr241Met (G > A, rs861539), XPD Lys751Gln (T > G, rs13181), and OGG1 Ser326Cys
(C > G, rs1052133) in the Maharashtrian population, residing in the Vidarbha region of central India
and to compare them with HapMap and other Indian populations. The variant alleles of these polymorphisms
have been found to be positively associated with different forms of cancer in several genetic epidemiological
studies. The basic prevalence of these polymorphisms in the general population must be
known to evaluate their significance in risk assessment in cancer and other phenotypes. About 215
healthy and unrelated individuals from the Maharashtrian population were genotyped for each of these
four polymorphisms using PCR–RFLP. The allele and genotype frequency distribution at the four DNA
repair gene loci among Maharashtrians revealed a characteristic pattern. To the best of our knowledge,
this is the first report of these DNA repair gene polymorphisms in a central Indian population
 
Publisher Elsevier
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/854/1/SreemantaChemosphere_2011.pdf
Pramanik, Sreemanta and Devi, Saravana and Surendran, Subin and Chowdhary, Sanghamitra and Krishnamurthi, Kannan and Chakrabarti, Tapan (2011) DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 loci in Maharashtrian population of central India. Chemosphere, 82. pp. 941-946. ISSN 0045-6535, ESSN: 1879-1298
 
Relation https://www.journals.elsevier.com/chemosphere/
http://neeri.csircentral.net/854/