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Polymorphisms in DNA repair and multidrug resistance genes among Sindhis of Central India

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Title Polymorphisms in DNA repair and multidrug resistance genes among Sindhis of Central India
 
Creator Pramanik, Sreemanta
Surendran, Subin
Arumugam, Sathishkumar
Devi, Saravana
Krishnamurthi, Kannan
Chakrabarti, Tapan
 
Subject Environmental Biotechnology
Environmental Health
 
Description Polymorphisms in DNA repair and multidrug resistance genes might contribute to interindividual and
interethnic differences in DNA repair capacity and drug disposition respectively. In the present study, we
determined the allele and genotype frequencies of four single nucleotide polymorphisms (SNPs) located
in the DNA repair genes, XRCC1, XRCC3, XPD, OGG1, namely XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD
Lys751Gln, and OGG1 Ser326Cys, respectively and two SNPs located in the multidrug resistance gene,
ABCB1, namely ABCB1 C3435T and ABCB1 C1236T, in 33–35 healthy and unrelated Sindhi individuals,
residing in the Vidarbha region of Central India and compared them with the Maharashtrian population
from the same geographical region and some other HapMap populations from the HapMap database. The
study findings reveal that the Indian Sindhis are closely related to the Maharashtrians as well as Utah
residents with Northern and Western European ancestry and Gujarati Indians in Houston, Texas in the
HapMap database.
 
Publisher Elsevier
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/855/1/Sreemanta_EnvToxPharmacol_2015.pdf
Pramanik, Sreemanta and Surendran, Subin and Arumugam, Sathishkumar and Devi, Saravana and Krishnamurthi, Kannan and Chakrabarti, Tapan (2015) Polymorphisms in DNA repair and multidrug resistance genes among Sindhis of Central India. Environmental Toxicology and Pharmacology, 40. pp. 480-485. ISSN 1382-6689 (Print) and 1872-7077 (Online)
 
Relation https://www.journals.elsevier.com/environmental-toxicology-and-pharmacology
http://neeri.csircentral.net/855/