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Neuromodulatory Potential of Aqueous Extracts of Cumin, Cinnamon: Evidence from Rotenone Model in Drosophila: Implications to Parkinson’s Disease.

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Relation http://ir.cftri.com/13250/
http://dx.doi.org/10.17554/j.issn.2313-5611.2016.02.60
 
Title Neuromodulatory Potential of Aqueous Extracts of Cumin, Cinnamon: Evidence from Rotenone Model in Drosophila: Implications to Parkinson’s Disease.
 
Creator Sriranjini, Venkata Rao
Greeshma, M.
Dr., Muralidhara
Rajini, P. S.
 
Subject 30 Spices/Condiments
32 Antioxidants
 
Description AIM: Spice extracts and their bioactive molecules have been well recognized for their innumerable beneficial effects against various chronic diseases. However, experimental data regarding their potential to abrogate oxidative stress and neurotoxicity in animal models of Parkinson’s disease (PD) are rather limited. In the current study, we aimed to assess the neuromodulatory potential of aqueous extracts of spices viz., cumin and cinnamon and their bioactives (Cuminaldehyde (CU) and Cinnamaldehyde (CN) using a rotenone (ROT) model of neurotoxicity in Drosophila.
MATERIALS AND METHODS: Adult male flies (Oregon K) were fed medium enriched (0.1-0.2%) with aqueous extract of Cumin or Cinnamon and their bio-actives (CU/ CN) with without ROT (500 μM) for 7 days. The propensity of extracts or bio-actives to protect flies against ROT-induced lethality, locomotor phenotype, oxidative stress and neurotoxicity was determined. While both the extracts significantly protected the flies against ROT-induced mortality, the survivors exhibited improved locomotor phenotype. Further both CU and CN-enrichment markedly reduced the ROT -induced lethality, diminished locomotor deficits and significantly abrogated the degree of oxidative impairments. Both bio-actives also augmented the antioxidant enzyme activities and restored ROT-induced mitochondrial dysfunctions. Interestingly, ROT -induced elevation of the activity of acetylcholinesterase and depletion of dopamine levels were also restored. Further, flies provided prophylactic treatment with bio-actives exhibited significant resistance to an acute exposure to Paraquat (PQ). In a parallel study, both bio-actives were found to significantly delay the onset of locomotor deficits among ROT-stressed flies besides extending their survival.
CONCLUSION: We hypothesise that the efficacy aqueous extract and their bioactives to attenuate ROT-mediated neurotoxicity may be largely related to the combined antioxidant activity of bio-actives resulting in improved locomotor performance, abrogation of oxidative stress and mitochondrial dysfunction. Based on these results, we propose that cumin and cinnamon extracts may be exploited as therapeutics against PD and other neurodegenerative diseases.
 
Date 2016
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13250/1/Int.%20J.%20Neurology%20Res.%202016%20December%3B%202%283-4%29%20297-307.pdf
Sriranjini, Venkata Rao and Greeshma, M. and Dr., Muralidhara and Rajini, P. S. (2016) Neuromodulatory Potential of Aqueous Extracts of Cumin, Cinnamon: Evidence from Rotenone Model in Drosophila: Implications to Parkinson’s Disease. International Journal of Neurology Research, 2 (3-4). pp. 297-307.